As a child Peter Parker left his parents and so was raised by his uncle and aunt. As the years passed, Peter was an ordinary exemplary school, attacked by bullies and was in love with his classmate Gwen Stacy, who himself secretly shared his feelings. But after being bitten by a genetically modified spider, Peter gets an incredible, supernatural experience, and his life changes forever.
However, he never ceases to torment the question of what happened to his parents. He met with his father's longtime friend and partner, the geneticist Curt Connors, who, along with his father Peter, developed the formula for regeneration. Peter helps her finish, and Connors, who has dreamed all his life of restoring his right hand, injects the formula into himself and becomes the Lizard. Pleading guilty, Piotr begins a new life as the mysterious superhero Spider-Man and becomes a menace of criminals while trying to find a way to stop the Connors.